Taken at bedtime for high levels upon waking before patients’
first levodopa dose
GOCOVRI QHS (once at bedtime) uses a time-dependent approach that's designed to provide an initial lag, a slow rise in amantadine concentration during the night, and a high concentration in the morning
through the entire waking day—when symptoms occur1,2
Gocovri QHS reaches high concentrations after ~8 hours1,2
- Pharmacokinetic data do not provide evidence of clinical safety or efficacy.
- These simulated data are derived from a steady-state PK study using the 137 mg QHS dose of GOCOVRI.
GOCOVRI QHS—starting and staying on the appropriate dose
Care should be taken in dose selection. Amantadine is excreted by the kidney. The majority of patients with PD are elderly and more likely to have decreased renal function1
If a dose is missed, the next dose should be taken as scheduled.1
Administration & discontinuation
- GOCOVRI can be taken with or without food
- GOCOVRI can be administered by carefully opening the capsule and sprinkling the entire contents in 1 teaspoon of soft food, such as applesauce
- Concomitant use of GOCOVRI with alcohol is not recommended
- Because rapid dose reduction or withdrawal may cause adverse reactions, it is recommended to avoid sudden discontinuation of GOCOVRI
- To avoid sudden discontinuation, patients who have taken GOCOVRI for more than 4 weeks should reduce their dose by half during their final week of dosing